Pair Name	Baicalin, Fluorouracil
Disease Info	[ICD-11: 2B72]	Gastric cancer		Investigative
Biological Phenomena	Induction-->ROS-related ferroptosis
Gene Regulation	Up-regulation	Expression	COX2	hsa4513
	Down-regulation	Expression	GPX4	hsa2879
	Up-regulation	Expression	NOX1	hsa27035
	Up-regulation	Expression	TFRC	hsa7037
In Vitro Model	SGC-7901	Human papillomavirus-related cervical adenocarcinoma	Homo sapiens (Human)	CVCL_0520
	AGS	Gastric adenocarcinoma	Homo sapiens (Human)	CVCL_0139
Result	Baicalin inhibits GC and enhances 5-Fu by promoting ROS-related ferroptosis in GC.

Pair Name	Baicalin, Fluorouracil
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->Proliferation
Gene Regulation	Down-regulation	Expression	CCND1	hsa595
	Down-regulation	Expression	CDK4	hsa1019
	Down-regulation	Expression	CDK6	hsa1021
	Down-regulation	Expression	DHFR	hsa1719
	Down-regulation	Expression	E2F1	hsa1869
	Up-regulation	Phosphorylation	NDRG1	hsa10397
	Down-regulation	Phosphorylation	RB1	hsa5925
	Down-regulation	Expression	TK1	hsa7083
	Down-regulation	Expression	TYMS	hsa7298
In Vitro Model	HT-29	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0320
	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
In Vivo Model	MC38 cells (2×10⁶ cells per mouse) were inoculated subcutaneously into the right flank of C57BL/6 mice.
Result	These results indicate that HQ and its component baicalin enhance the effect of 5-fluorouracil-based chemotherapy via inhibition of CDK-RB pathway. These findings may provide the rational basis for developing agents that can overcome the development of cellular drug resistance. Video Abstract.

Pair Name	Baicalin, Fluorouracil
Disease Info	[ICD-11: 2A00-2F9Z]	Solid tumour or cancer		Investigative
Biological Phenomena	Inhibition-->Vasculogenic mimicry
Gene Regulation	Up-regulation	Expression	BAX	hsa581
	Down-regulation	Expression	BCL2	hsa596
	Up-regulation	Expression	CASP3	hsa836
	Down-regulation	Expression	IL1B	hsa3553
	Down-regulation	Expression	NFKB1	hsa4790
	Up-regulation	Expression	TP53	hsa7157
	Down-regulation	Expression	VEGFA	hsa7422
In Vitro Model	EAC-E2G8	Malignant neoplasms of the mouse mammary gland	Mus musculus (Mouse)	CVCL_WJ08
In Vivo Model	EAC cells were suspended in sterile isotonic saline to reach a fixed concentration of 2.5 million EAC cells in 0.1 mL of suspension.
Result	BA is a promising preventive or adjuvant therapy in breast cancer treatment with 5-FU mainly via cooperative inhibition of inflammation, angiogenesis, and triggering apoptotic cell death.